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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Lysine-specific histone demethylase 1A

SKU : BHE13805581

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12881h
Alternative Names	BRAF35-HDAC complex protein BHC110 ; Flavin-containing amine oxidase domain-containing protein 2 ; AOF2 ; KDM1 ; KIAA0601 ; LSD1
Categories	Elisa
Function	Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis.
Specificity	Natural and recombinant Human Lysine-specific histone demethylase 1A
Subcellular Location	Nucleus
Detection Range	0.312-20ng/ml
Entryname	KDM1A_HUMAN
Method Type	Sandwich
Platform	PF01593
Protein Name	Lysine-specific histone demethylase 1A
Sensitivity	0.179ng/mL
Sequence	50: MLSGKKAAAA ; AAAAAAAATG ; TEAGPGTAGG ; SENGSEVAAQ ; PAGLSGPAEV ; 100: GPGAVGERTP ; RKKEPPRASP ; PGGLAEPPGS ; AGPQAGPTVV ; PGSATPMETG ; 150: IAETPEGRRT ; SRRKRAKVEY ; REMDESLANL ; SEDEYYSEEE ; RNAKAEKEKK ; 200: LPPPPPQAPP ; EEENESEPEE ; PSGVEGAAFQ ; SRLPHDRMTS ; QEAACFPDII ; 250: SGPQQTQKVF ; LFIRNRTLQL ; WLDNPKIQLT ; FEATLQQLEA ; PYNSDTVLVH ; 300: RVHSYLERHG ; LINFGIYKRI ; KPLPTKKTGK ; VIIIGSGVSG ; LAAARQLQSF ; 350: GMDVTLLEAR ; DRVGGRVATF ; RKGNYVADLG ; AMVVTGLGGN ; PMAVVSKQVN ; 400: MELAKIKQKC ; PLYEANGQAV ; PKEKDEMVEQ ; EFNRLLEATS ; YLSHQLDFNV ; 450: LNNKPVSLGQ ; ALEVVIQLQE ; KHVKDEQIEH ; WKKIVKTQEE ; LKELLNKMVN ; 500: LKEKIKELHQ ; QYKEASEVKP ; PRDITAEFLV ; KSKHRDLTAL ; CKEYDELAET ; 550: QGKLEEKLQE ; LEANPPSDVY ; LSSRDRQILD ; WHFANLEFAN ; ATPLSTLSLK ; 600: HWDQDDDFEF ; TGSHLTVRNG ; YSCVPVALAE ; GLDIKLNTAV ; RQVRYTASGC ; 650: EVIAVNTRST ; SQTFIYKCDA ; VLCTLPLGVL ; KQQPPAVQFV ; PPLPEWKTSA ; 700: VQRMGFGNLN ; KVVLCFDRVF ; WDPSVNLFGH ; VGSTTASRGE ; LFLFWNLYKA ; 750: PILLALVAGE ; AAGIMENISD ; DVIVGRCLAI ; LKGIFGSSAV ; PQPKETVVSR ; 800: WRADPWARGS ; YSYVAAGSSG ; NDYDLMAQPI ; TPGPSIPGAP ; QPIPRLFFAG ; 850: EHTIRNYPAT ; VHGALLSGLR ; EAGRIADQFL ; GAMYTLPRQA ; TPGVPAQQSP ; 852: SM
Sequence Length	852
String	O60341
Sub Unit	Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR).

Uniprot	O60341
Gene Name	KDM1A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:23028
Unigene	Hs.591518

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805581	E12881h	96T	$736		Add to Cart

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