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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Lymphoid enhancer-binding factor 1

SKU : BHE13806307

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15267h
Alternative Names	T cell-specific transcription factor 1-alpha ; TCF1-alpha
Categories	Elisa
Function	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Specificity	Natural and recombinant Human Lymphoid enhancer-binding factor 1
Subcellular Location	Nucleus Found in nuclear bodies upon PIASG binding.
Detection Range	78-5000pg/mL
Entryname	LEF1_HUMAN
Method Type	Sandwich
Platform	PF08347
Protein Name	Lymphoid enhancer-binding factor 1
Sensitivity	38pg/mL
Sequence	50: MPQLSGGGGG ; GGGDPELCAT ; DEMIPFKDEG ; DPQKEKIFAE ; ISHPEEEGDL ; 100: ADIKSSLVNE ; SEIIPASNGH ; EVARQAQTSQ ; EPYHDKAREH ; PDDGKHPDGG ; 150: LYNKGPSYSS ; YSGYIMMPNM ; NNDPYMSNGS ; LSPPIPRTSN ; KVPVVQPSHA ; 200: VHPLTPLITY ; SDEHFSPGSH ; PSHIPSDVNS ; KQGMSRHPPA ; PDIPTFYPLS ; 250: PGGVGQITPP ; LGWQGQPVYP ; ITGGFRQPYP ; SSLSVDTSMS ; RFSHHMIPGP ; 300: PGPHTTGIPH ; PAIVTPQVKQ ; EHPHTDSDLM ; HVKPQHEQRK ; EQEPKRPHIK ; 350: KPLNAFMLYM ; KEMRANVVAE ; CTLKESAAIN ; QILGRRWHAL ; SREEQAKYYE ; 399: LARKERQLHM ; QLYPGWSARD ; NYGKKKKRKR ; EKLQESASGT ; GPRMTAAYI
Sequence Length	399
String	Q9UJU2
Sub Unit	Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC. Interacts with NLK.

Uniprot	Q9UJU2
Gene Name	LEF1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51176
Unigene	Hs.726506

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806307	E15267h	96T	$736		Add to Cart

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