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ELISA Kit for Human Lymphatic vessel endothelial hyaluronic acid receptor 1

SKU : BHE13807090

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13600h
Alternative Names	Cell surface retention sequence-binding protein 1 ; CRSBP-1 ; Extracellular link domain-containing protein 1 ; Hyaluronic acid receptor ; CRSBP1 ; HAR ; XLKD1 ; UNQ230/PRO263
Categories	Elisa
Function	Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Specificity	Natural and recombinant Human Lymphatic vessel endothelial hyaluronic acid receptor 1
Subcellular Location	Membrane Single-pass type I membrane protein Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Detection Range	78-5000pg/mL
Entryname	LYVE1_HUMAN
Method Type	Sandwich
Platform	PF00193
Protein Name	Lymphatic vessel endothelial hyaluronic acid receptor 1
Sensitivity	39.9pg/mL
Sequence	50: MARCFSLVLL ; LTSIWTTRLL ; VQGSLRAEEL ; SIQVSCRIMG ; ITLVSKKANQ ; 100: QLNFTEAKEA ; CRLLGLSLAG ; KDQVETALKA ; SFETCSYGWV ; GDGFVVISRI ; 150: SPNPKCGKNG ; VGVLIWKVPV ; SRQFAAYCYN ; SSDTWTNSCI ; PEIITTKDPI ; 200: FNTQTATQTT ; EFIVSDSTYS ; VASPYSTIPA ; PTTTPPAPAS ; TSIPRRKKLI ; 250: CVTEVFMETS ; TMSTETEPFV ; ENKAAFKNEA ; AGFGGVPTAL ; LVLALLFFGA ; 300: AAGLGFCYVK ; RYVKAFPFTN ; KNQQKEMIET ; KVVKEEKAND ; SNPNEESKKT ; 322: DKNPEESKSP ; SKTTVRCLEA ; EV
Sequence Length	322
String	Q9Y5Y7
Sub Unit	Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.

Uniprot	Q9Y5Y7
Gene Name	LYVE1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10894
Unigene	Hs.655332

Reference	1. "LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific receptor for hyaluronan." Banerji S., Ni J., Wang S.-X., Clasper S., Su J., Tammi R., Jones M., Jackson D.G. J. Cell Biol.144:789-801(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 2. "HAR: a novel homolog of CD44 and putative hyaluronic acid receptor encoded by a gene on human chromosome 11p15." Winkelmann J.C., Basu S., Ozdemir E., Blough R.I. Submitted (1999-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.more... Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-116 tissue: Liver. 5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53 tissue: Plasma. 6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53 tissue: Liver.

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BHE13807090	E13600h	96T	$736		Add to Cart

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