Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
Specificity
Natural and recombinant Human Low-density lipoprotein receptor-related protein 4
"Low density lipoprotein receptor-related protein 10." Ishikawa K., Fujimoto H., Kim D., Saeki S. Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE REGULATION OF CANONICAL WTN SIGNALING;VARIANTS CLSS ASN-137; TYR-160; ASN-449; PRO-461; PHE-473; ASN-529 AND ARG-1017;CHARACTERIZATION OF VARIANTS CLSS ASN-137; TYR-160; ASN-449; PHE-473 AND ASN-529
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SOST;TISSUE SPECIFICITY;VARIANTS SOST2 TRP-1170 AND SER-1186;CHARACTERIZATION OF VARIANTS SOST2 TRP-1170 AND SER-1186;IDENTIFICATION BY MASS SPECTROMETRY
Reviews of ELISA Kit for Human Low-density lipoprotein receptor-related protein 4