CD85 antigen-like family member K ; Immunoglobulin-like transcript 3 ; ILT-3 ; Leukocyte immunoglobulin-like receptor 5 ; LIR-5 ; Monocyte inhibitory receptor HM18 ; CD85k ; ILT3 ; LIR5
Categories
Elisa
Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Specificity
Natural and recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4
Subcellular Location
Cell membrane Single-pass type I membrane protein Ligand binding leads to internalization and translocation to an antigen-processing compartment.