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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Kelch-like ECH-associated protein 1

SKU : BHE13806331

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2835h
Alternative Names	Cytosolic inhibitor of Nrf2 ; INrf2 ; Kelch-like protein 19 ; INRF2 ; KIAA0132 ; KLHL19
Categories	Elisa
Function	Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Specificity	Natural and recombinant Human Kelch-like ECH-associated protein 1
Subcellular Location	Cytoplasm Nucleus Shuttles between cytoplasm and nucleus.
Detection Range	78-5000pg/mL
Entryname	KEAP1_HUMAN
Method Type	Sandwich
Platform	PF07707
Protein Name	Kelch-like ECH-associated protein 1
Sensitivity	40.6pg/mL
Sequence	50: MQPDPRPSGA ; GACCRFLPLQ ; SQCPEGAGDA ; VMYASTECKA ; EVTPSQHGNR ; 100: TFSYTLEDHT ; KQAFGIMNEL ; RLSQQLCDVT ; LQVKYQDAPA ; AQFMAHKVVL ; 150: ASSSPVFKAM ; FTNGLREQGM ; EVVSIEGIHP ; KVMERLIEFA ; YTASISMGEK ; 200: CVLHVMNGAV ; MYQIDSVVRA ; CSDFLVQQLD ; PSNAIGIANF ; AEQIGCVELH ; 250: QRAREYIYMH ; FGEVAKQEEF ; FNLSHCQLVT ; LISRDDLNVR ; CESEVFHACI ; 300: NWVKYDCEQR ; RFYVQALLRA ; VRCHSLTPNF ; LQMQLQKCEI ; LQSDSRCKDY ; 350: LVKIFEELTL ; HKPTQVMPCR ; APKVGRLIYT ; AGGYFRQSLS ; YLEAYNPSDG ; 400: TWLRLADLQV ; PRSGLAGCVV ; GGLLYAVGGR ; NNSPDGNTDS ; SALDCYNPMT ; 450: NQWSPCAPMS ; VPRNRIGVGV ; IDGHIYAVGG ; SHGCIHHNSV ; ERYEPERDEW ; 500: HLVAPMLTRR ; IGVGVAVLNR ; LLYAVGGFDG ; TNRLNSAECY ; YPERNEWRMI ; 550: TAMNTIRSGA ; GVCVLHNCIY ; AAGGYDGQDQ ; LNSVERYDVE ; TETWTFVAPM ; 600: KHRRSALGIT ; VHQGRIYVLG ; GYDGHTFLDS ; VECYDPDTDT ; WSEVTRMTSG ; 624: RSGVGVAVTM ; EPCRKQIDQQ ; NCTC
Sequence Length	624
String	Q14145
Sub Unit	Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

Uniprot	Q14145
Gene Name	KEAP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9817
Unigene	Hs.465870

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806331	E2835h	96T	$736		Add to Cart

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