Huntingtin-associated protein-interacting protein ; Protein Duo ; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain ; DUET ; DUO ; HAPIP ; TRAD
Categories
Elisa
Function
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Specificity
Natural and recombinant Human Kalirin
Subcellular Location
Cytoplasm Cytoplasm cytoskeleton Associated with the cytoskeleton.
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.