High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
Specificity
Natural and recombinant Human Interleukin-15 receptor subunit alpha
Subcellular Location
Soluble interleukin-15 receptor subunit alpha Secreted extracellular space