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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Integrin beta-3

SKU : BHE13806660

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15079h
Alternative Names	Platelet membrane glycoprotein IIIa ; GPIIIa ; CD61 ; GP3A
Categories	Elisa
Function	Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Specificity	Natural and recombinant Human Integrin beta-3
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	78-5000pg/mL
Entryname	ITB3_HUMAN
Method Type	Sandwich
Platform	PF07974
Protein Name	Integrin beta-3
Sensitivity	40pg/mL
Sequence	50: MRARPRPRPL ; WATVLALGAL ; AGVGVGGPNI ; CTTRGVSSCQ ; QCLAVSPMCA ; 100: WCSDEALPLG ; SPRCDLKENL ; LKDNCAPESI ; EFPVSEARVL ; EDRPLSDKGS ; 150: GDSSQVTQVS ; PQRIALRLRP ; DDSKNFSIQV ; RQVEDYPVDI ; YYLMDLSYSM ; 200: KDDLWSIQNL ; GTKLATQMRK ; LTSNLRIGFG ; AFVDKPVSPY ; MYISPPEALE ; 250: NPCYDMKTTC ; LPMFGYKHVL ; TLTDQVTRFN ; EEVKKQSVSR ; NRDAPEGGFD ; 300: AIMQATVCDE ; KIGWRNDASH ; LLVFTTDAKT ; HIALDGRLAG ; IVQPNDGQCH ; 350: VGSDNHYSAS ; TTMDYPSLGL ; MTEKLSQKNI ; NLIFAVTENV ; VNLYQNYSEL ; 400: IPGTTVGVLS ; MDSSNVLQLI ; VDAYGKIRSK ; VELEVRDLPE ; ELSLSFNATC ; 450: LNNEVIPGLK ; SCMGLKIGDT ; VSFSIEAKVR ; GCPQEKEKSF ; TIKPVGFKDS ; 500: LIVQVTFDCD ; CACQAQAEPN ; SHRCNNGNGT ; FECGVCRCGP ; GWLGSQCECS ; 550: EEDYRPSQQD ; ECSPREGQPV ; CSQRGECLCG ; QCVCHSSDFG ; KITGKYCECD ; 600: DFSCVRYKGE ; MCSGHGQCSC ; GDCLCDSDWT ; GYYCNCTTRT ; DTCMSSNGLL ; 650: CSGRGKCECG ; SCVCIQPGSY ; GDTCEKCPTC ; PDACTFKKEC ; VECKKFDRGA ; 700: LHDENTCNRY ; CRDEIESVKE ; LKDTGKDAVN ; CTYKNEDDCV ; VRFQYYEDSS ; 750: GKSILYVVEE ; PECPKGPDIL ; VVLLSVMGAI ; LLIGLAALLI ; WKLLITIHDR ; 788: KEFAKFEEER ; ARAKWDTANN ; PLYKEATSTF ; TNITYRGT
Sequence Length	788
String	P05106
Sub Unit	Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation.

Uniprot	P05106
Gene Name	ITGB3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3690
Unigene	Hs.218040

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806660	E15079h	96T	$736		Add to Cart

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