Basic-helix-loop-helix-PAS protein MOP7 ; Class E basic helix-loop-helix protein 17 ; bHLHe17 ; HIF3-alpha-1 ; Inhibitory PAS domain protein ; IPAS ; Member of PAS protein 7 ; PAS domain-containing protein 7 ; BHLHE17 ; MOP7 ; PASD7
Categories
Elisa
Function
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
Specificity
Natural and recombinant Human Hypoxia-inducible factor 3-alpha
Subcellular Location
Nucleus Cytoplasm In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes.