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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Histone H3.3

SKU : BHE13805186

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5810h
Alternative Names	H3.3A ; H3F3 ; PP781
Categories	Elisa
Function	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Specificity	Natural and recombinant Human Histone H3.3
Subcellular Location	Nucleus Chromosome
Detection Range	0.312-20ng/mL
Entryname	H33_HUMAN
Method Type	Sandwich
Platform	PF00125
Protein Name	Histone H3.3
Sensitivity	0.181ng/mL
Sequence	50: MARTKQTARK ; STGGKAPRKQ ; LATKAARKSA ; PSTGGVKKPH ; RYRPGTVALR ; 100: EIRRYQKSTE ; LLIRKLPFQR ; LVREIAQDFK ; TDLRFQSAAI ; GALQEASEAY ; 136: LVGLFEDTNL ; CAIHAKRVTI ; MPKDIQLARR ; IRGERA
Sequence Length	136
String	P84243
Sub Unit	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes.

Uniprot	P84243
Gene Name	H3F3A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3020
Unigene	Hs.180877

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805186	E5810h	96T	$736		Add to Cart

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