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Home / Assay Kits / ELISA Kits

ELISA Kit for Human High affinity nerve growth factor receptor

SKU : BHE13808384

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9557h
Alternative Names	Neurotrophic tyrosine kinase receptor type 1 ; TRK1-transforming tyrosine kinase protein ; Tropomyosin-related kinase A ; Tyrosine kinase receptor ; Tyrosine kinase receptor A ; Trk-A ; gp140trk ; p140-TrkA ; MTC ; TRK ; TRKA
Categories	Elisa
Function	Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Specificity	Natural and recombinant Human High affinity nerve growth factor receptor
Subcellular Location	Cell membrane Single-pass type I membrane protein Endocytosed to the endosomes upon treatment of cells with NGF.
Detection Range	78-5000pg/mL
Entryname	NTRK1_HUMAN
Method Type	Sandwich
Platform	PF07714
Protein Name	High affinity nerve growth factor receptor
Sensitivity	24pg/mL
Sequence	50: MLRGGRRGQL ; GWHSWAAGPG ; SLLAWLILAS ; AGAAPCPDAC ; CPHGSSGLRC ; 100: TRDGALDSLH ; HLPGAENLTE ; LYIENQQHLQ ; HLELRDLRGL ; GELRNLTIVK ; 150: SGLRFVAPDA ; FHFTPRLSRL ; NLSFNALESL ; SWKTVQGLSL ; QELVLSGNPL ; 200: HCSCALRWLQ ; RWEEEGLGGV ; PEQKLQCHGQ ; GPLAHMPNAS ; CGVPTLKVQV ; 250: PNASVDVGDD ; VLLRCQVEGR ; GLEQAGWILT ; ELEQSATVMK ; SGGLPSLGLT ; 300: LANVTSDLNR ; KNVTCWAEND ; VGRAEVSVQV ; NVSFPASVQL ; HTAVEMHHWC ; 350: IPFSVDGQPA ; PSLRWLFNGS ; VLNETSFIFT ; EFLEPAANET ; VRHGCLRLNQ ; 400: PTHVNNGNYT ; LLAANPFGQA ; SASIMAAFMD ; NPFEFNPEDP ; IPVSFSPVDT ; 450: NSTSGDPVEK ; KDETPFGVSV ; AVGLAVFACL ; FLSTLLLVLN ; KCGRRNKFGI ; 500: NRPAVLAPED ; GLAMSLHFMT ; LGGSSLSPTE ; GKGSGLQGHI ; IENPQYFSDA ; 550: CVHHIKRRDI ; VLKWELGEGA ; FGKVFLAECH ; NLLPEQDKML ; VAVKALKEAS ; 600: ESARQDFQRE ; AELLTMLQHQ ; HIVRFFGVCT ; EGRPLLMVFE ; YMRHGDLNRF ; 650: LRSHGPDAKL ; LAGGEDVAPG ; PLGLGQLLAV ; ASQVAAGMVY ; LAGLHFVHRD ; 700: LATRNCLVGQ ; GLVVKIGDFG ; MSRDIYSTDY ; YRVGGRTMLP ; IRWMPPESIL ; 750: YRKFTTESDV ; WSFGVVLWEI ; FTYGKQPWYQ ; LSNTEAIDCI ; TQGRELERPR ; 796: ACPPEVYAIM ; RGCWQREPQQ ; RHSIKDVHAR ; LQALAQAPPV ; YLDVLG
Sequence Length	796
String	P04629
Sub Unit	Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with KIDINS220 and NGFR. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.

Uniprot	P04629
Gene Name	NTRK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4914
Unigene	Hs.406293

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808384	E9557h	96T	$736		Add to Cart

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