Transformation up-regulated nuclear protein ; TUNP ; HNRPK
Categories
Elisa
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA.
Specificity
Natural and recombinant Human Heterogeneous nuclear ribonucleoprotein K
Subcellular Location
Cytoplasm Nucleus nucleoplasm In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.
Interacts with RBM42 and ZIK1 (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1.