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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Gamma-secretase subunit APH-1A

SKU : BHE13800975

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0406h
Alternative Names	Aph-1alpha ; Presenilin-stabilization factor ; PSF ; CGI-78 ; UNQ579/PRO1141
Categories	Elisa
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Specificity	Natural and recombinant Human Gamma-secretase subunit APH-1A
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus Golgi stack membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Detection Range	1.56-100ng/mL
Entryname	APH1A_HUMAN
Method Type	Sandwich
Platform	PF06105
Protein Name	Gamma-secretase subunit APH-1A
Sensitivity	0.78ng/mL
Sequence	50: MGAAVFFGCT ; FVAFGPAFAL ; FLITVAGDPL ; RVIILVAGAF ; FWLVSLLLAS ; 100: VVWFILVHVT ; DRSDARLQYG ; LLIFGAAVSV ; LLQEVFRFAY ; YKLLKKADEG ; 150: LASLSEDGRS ; PISIRQMAYV ; SGLSFGIISG ; VFSVINILAD ; ALGPGVVGIH ; 200: GDSPYYFLTS ; AFLTAAIILL ; HTFWGVVFFD ; ACERRRYWAL ; GLVVGSHLLT ; 250: SGLTFLNPWY ; EASLLPIYAV ; TVSMGLWAFI ; TAGGSLRSIQ ; RSLLCRRQED ; 265: SRVMVYSALR ; IPPED
Sequence Length	265
String	Q96BI3
Sub Unit	Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.

Uniprot	Q96BI3
Gene Name	APH1A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51107
Unigene	Hs.108408

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800975	E0406h	96T	$736		Add to Cart

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