Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. Isoform 2 exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2.
Specificity
Natural and recombinant Human Galanin-like peptide
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2.
"Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family." Kofler B., Moritz K., Fenninger K. Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
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