Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
Specificity
Natural and recombinant Human Free fatty acid receptor 1
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-211
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-12; TYR-91; HIS-137; ARG-183; TYR-240; ASN-244 AND ARG-258
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLU-145 AND GLU-172;SITE
7.
"Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40." Kruska N., Reiser G. Neurobiol. Dis.43:465-472(2011) [PubMed] [Europe PMC] [Abstract]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 1-211 AND 214-300 IN COMPLEX WITH THE AGONIST TAK-875;AGONIST BINDING SITES;SUBCELLULAR LOCATION;TOPOLOGY;DISULFIDE BOND;MUTAGENESIS OF TYR-91; ARG-183; TYR-240; ASN-244 AND ARG-258
Reviews of ELISA Kit for Human Free fatty acid receptor 1