JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Flap endonuclease 1

SKU : BHE13804054

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E15243h
Alternative Names	DNase IV ; Flap structure-specific endonuclease 1 ; Maturation factor 1 ; MF1 ; RAD2
Categories	Elisa
Function	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Specificity	Natural and recombinant Human Flap endonuclease 1
Subcellular Location	Nucleus nucleolus Nucleus nucleoplasm Mitochondrion Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Detection Range	0.312-20ng/mL
Entryname	FEN1_HUMAN
Method Type	Competitive
Platform	PF00867
Protein Name	Flap endonuclease 1
Sensitivity	0.136ng/mL
Sequence	50: MGIQGLAKLI ; ADVAPSAIRE ; NDIKSYFGRK ; VAIDASMSIY ; QFLIAVRQGG ; 100: DVLQNEEGET ; TSHLMGMFYR ; TIRMMENGIK ; PVYVFDGKPP ; QLKSGELAKR ; 150: SERRAEAEKQ ; LQQAQAAGAE ; QEVEKFTKRL ; VKVTKQHNDE ; CKHLLSLMGI ; 200: PYLDAPSEAE ; ASCAALVKAG ; KVYAAATEDM ; DCLTFGSPVL ; MRHLTASEAK ; 250: KLPIQEFHLS ; RILQELGLNQ ; EQFVDLCILL ; GSDYCESIRG ; IGPKRAVDLI ; 300: QKHKSIEEIV ; RRLDPNKYPV ; PENWLHKEAH ; QLFLEPEVLD ; PESVELKWSE ; 350: PNEEELIKFM ; CGEKQFSEER ; IRSGVKRLSK ; SRQGSTQGRL ; DDFFKVTGSL ; 380: SSAKRKEPEP ; KGSTKKKAKT ; GAAGKFKRGK ;
Sequence Length	380
String	P39748
Sub Unit	Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.

Uniprot	P39748
Gene Name	FEN1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2237
Unigene	Hs.409065

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13804054	E15243h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.