ABP-280-like protein ; ABP-L ; Actin-binding-like protein ; Filamin-2 ; Gamma-filamin ; ABPL ; FLN2
Categories
Elisa
Function
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Specificity
Natural and recombinant Human Filamin-C
Subcellular Location
Cytoplasm Membrane Peripheral membrane protein Cytoplasm cytoskeleton Cytoplasm myofibril sarcomere Z line A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme.
Homodimer. Interacts with KY. Interacts with IGFN1 (By similarity). Interacts with FLNB, KCND2, ITGB1A, INPPL1, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only).