Endoplasmic reticulum oxidoreductase beta ; Endoplasmic reticulum oxidoreductin-1-like protein B ; Oxidoreductin-1-L-beta ; ERO1LB
Categories
Elisa
Function
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.
Specificity
Natural and recombinant Human ERO1-like protein beta
Subcellular Location
Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side The association with ERP44 may be essential for its retention in the endoplasmic reticulum.