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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Ephrin-A1

SKU : BHE13803951

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1422h
Alternative Names	EPH-related receptor tyrosine kinase ligand 1 ; LERK-1 ; Immediate early response protein B61 ; Tumor necrosis factor alpha-induced protein 4 ; TNF alpha-induced protein 4 ; EPLG1 ; LERK1 ; TNFAIP4
Categories	Elisa
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Specificity	Natural and recombinant Human Ephrin-A1
Subcellular Location	Ephrin-A1, secreted form Secreted
Detection Range	0.156-10ng/mL
Entryname	EFNA1_HUMAN
Method Type	Sandwich
Platform	PF00812
Protein Name	Ephrin-A1
Sensitivity	0.098ng/mL
Sequence	50: MEFLWAPLLG ; LCCSLAAADR ; HTVFWNSSNP ; KFRNEDYTIH ; VQLNDYVDII ; 100: CPHYEDHSVA ; DAAMEQYILY ; LVEHEEYQLC ; QPQSKDQVRW ; QCNRPSAKHG ; 150: PEKLSEKFQR ; FTPFTLGKEF ; KEGHSYYYIS ; KPIHQHEDRC ; LRLKVTVSGK ; 200: ITHSPQAHDN ; PQEKRLAADD ; PEVRVLHSIG ; HSAAPRLFPL ; AWTVLLLPLL ; 205: LLQTP
Sequence Length	205
String	P20827
Sub Unit	Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.

Uniprot	P20827
Gene Name	EFNA1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1942
Unigene	Hs.516664

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803951	E1422h	96T	$736		Add to Cart

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