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ELISA Kit for Human Endothelial PAS domain-containing protein 1

SKU : BHE13804354

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2004h
Alternative Names	Basic-helix-loop-helix-PAS protein MOP2 ; Class E basic helix-loop-helix protein 73 ; bHLHe73 ; HIF-1-alpha-like factor ; HLF ; Hypoxia-inducible factor 2-alpha ; HIF-2-alpha ; Member of PAS protein 2 ; PAS domain-containing protein 2 ; BHLHE73 ; HIF2A ; MOP2 ; PASD2
Categories	Elisa
Function	Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Specificity	Natural and recombinant Human Endothelial PAS domain-containing protein 1
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	EPAS1_HUMAN
Method Type	Sandwich
Platform	PF11413
Protein Name	Endothelial PAS domain-containing protein 1
Sensitivity	0.078ng/mL
Sequence	50: MTADKEKKRS ; SSERRKEKSR ; DAARCRRSKE ; TEVFYELAHE ; LPLPHSVSSH ; 100: LDKASIMRLA ; ISFLRTHKLL ; SSVCSENESE ; AEADQQMDNL ; YLKALEGFIA ; 150: VVTQDGDMIF ; LSENISKFMG ; LTQVELTGHS ; IFDFTHPCDH ; EEIRENLSLK ; 200: NGSGFGKKSK ; DMSTERDFFM ; RMKCTVTNRG ; RTVNLKSATW ; KVLHCTGQVK ; 250: VYNNCPPHNS ; LCGYKEPLLS ; CLIIMCEPIQ ; HPSHMDIPLD ; SKTFLSRHSM ; 300: DMKFTYCDDR ; ITELIGYHPE ; ELLGRSAYEF ; YHALDSENMT ; KSHQNLCTKG ; 350: QVVSGQYRML ; AKHGGYVWLE ; TQGTVIYNPR ; NLQPQCIMCV ; NYVLSEIEKN ; 400: DVVFSMDQTE ; SLFKPHLMAM ; NSIFDSSGKG ; AVSEKSNFLF ; TKLKEEPEEL ; 450: AQLAPTPGDA ; IISLDFGNQN ; FEESSAYGKA ; ILPPSQPWAT ; ELRSHSTQSE ; 500: AGSLPAFTVP ; QAAAPGSTTP ; SATSSSSSCS ; TPNSPEDYYT ; SLDNDLKIEV ; 550: IEKLFAMDTE ; AKDQCSTQTD ; FNELDLETLA ; PYIPMDGEDF ; QLSPICPEER ; 600: LLAENPQSTP ; QHCFSAMTNI ; FQPLAPVAPH ; SPFLLDKFQQ ; QLESKKTEPE ; 650: HRPMSSIFFD ; AGSKASLPPC ; CGQASTPLSS ; MGGRSNTQWP ; PDPPLHFGPT ; 700: KWAVGDQRTE ; FLGAAPLGPP ; VSPPHVSTFK ; TRSAKGFGAR ; GPDVLSPAMV ; 750: ALSNKLKLKR ; QLEYEEQAFQ ; DLSGGDPPGG ; STSHLMWKRM ; KNLRGGSCPL ; 800: MPDKPLSANV ; PNDKFTQNPM ; RGLGHPLRHL ; PLPQPPSAIS ; PGENSKSRFP ; 850: PQCYATQYQD ; YSLSSAHKVS ; GMASRLLGPS ; FESYLLPELT ; RYDCEVNVPV ; 870: LGSSTLLQGG ; DLLRALDQAT ;
Sequence Length	870
String	Q99814
Sub Unit	Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP.

Uniprot	Q99814
Gene Name	EPAS1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2034
Unigene	Hs.468410

Reference	1. "Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells." Tian H., McKnight S.L., Russell D.W. Genes Dev.11:72-82(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway." Hogenesch J.B., Chan W.K., Jackiw V.H., Brown R.C., Gu Y.-Z., Pray-Grant M., Perdew G.H., Bradfield C.A. J. Biol. Chem.272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Hepatoma. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Eye. 4. "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300." Ema M., Hirota K., Mimura J., Abe H., Yodoi J., Sogawa K., Poellinger L., Fujii-Kuriyama Y. EMBO J.18:1905-1914(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSACTIVATION DOMAINS NTAD AND CTAD;INTERACTION WITH APEX;MUTAGENESIS OF CYS-844 5. "Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline." Furlow P.W., Percy M.J., Sutherland S., Bierl C., McMullin M.F., Master S.R., Lappin T.R., Lee F.S. J. Biol. Chem.284:9050-9058(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN1 AND VHL;VARIANT ECYT4 LEU-534;CHARACTERIZATION OF VARIANTS ECYT4 LEU-534; VAL-535 AND ARG-537 6. "Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis." Percy M.J., Beer P.A., Campbell G., Dekker A.W., Green A.R., Oscier D., Rainey M.G., van Wijk R., Wood M., Lappin T.R., McMullin M.F., Lee F.S. Blood111:5400-5402(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT4 VAL-535 AND ARG-537 7. "A gain-of-function mutation in the HIF2A gene in familial erythrocytosis." Percy M.J., Furlow P.W., Lucas G.S., Li X., Lappin T.R., McMullin M.F., Lee F.S. N. Engl. J. Med.358:162-168(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECYT4 TRP-537;IDENTIFICATION BY MASS SPECTROMETRY;CHARACTERIZATION OF VARIANT ECYT4 TRP-537 8. "Two new mutations in the HIF2A gene associated with erythrocytosis." Percy M.J., Chung Y.J., Harrison C., Mercieca J., Hoffbrand A.V., Dinardo C.L., Santos P.C., Fonseca G.H., Gualandro S.F., Pereira A.C., Lappin T.R., McMullin M.F., Lee F.S. Am. J. Hematol.87:439-442(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT4 THR-535 AND LEU-540;CHARACTERIZATION OF VARIANT ECYT4 LEU-540

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