94 kDa glucose-regulated protein ; GRP-94 ; Heat shock protein 90 kDa beta member 1 ; Tumor rejection antigen 1 ; gp96 homolog ; GRP94 ; TRA1
Categories
Elisa
Function
Molecular chaperone that functions in the processing and transport of secreted proteins. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Specificity
Natural and recombinant Human Endoplasmin
Subcellular Location
Endoplasmic reticulum lumen Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9.