ELISA Kit for Human Elongin-B

Mfr.No.	E15274h
Alternative Names	Elongin 18 kDa subunit ; RNA polymerase II transcription factor SIII subunit B ; SIII p18 ; Transcription elongation factor B polypeptide 2 ; TCEB2
Categories	Elisa
Function	The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Specificity	Natural and recombinant Human Elongin-B
Subcellular Location	Nucleus
Detection Range	78-5000pg/mL
Entryname	ELOB_HUMAN
Method Type	Sandwich
Platform	PF00240
Protein Name	Elongin-B
Sensitivity	34pg/mL
Sequence	50: MDVFLMIRRH ; KTTIFTDAKE ; SSTVFELKRI ; VEGILKRPPD ; EQRLYKDDQL ; 100: LDDGKTLGEC ; GFTSQTARPQ ; APATVGLAFR ; ADDTFEALCI ; EPFSSPPELP ; 118: DVMKPQDSGS ; SANEQAVQ
Sequence Length	118
String	Q15370
Sub Unit	Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, TCEB3, VHL or WSB1 (By similarity). Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804117	E15274h	96T	$736		Add to Cart