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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Dynein light chain 1, cytoplasmic

SKU : BHE13803559

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13866h
Alternative Names	8 kDa dynein light chain ; DLC8 ; Dynein light chain LC8-type 1 ; Protein inhibitor of neuronal nitric oxide synthase ; PIN ; DLC1 ; DNCL1 ; DNCLC1 ; HDLC1
Categories	Elisa
Function	Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Specificity	Natural and recombinant Human Dynein light chain 1, cytoplasmic
Subcellular Location	Cytoplasm cytoskeleton Nucleus Mitochondrion Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Entryname	DYL1_HUMAN
Platform	PF01221
Protein Name	Dynein light chain 1, cytoplasmic
Sequence	50: MCDRKAVIKN ; ADMSEEMQQD ; SVECATQALE ; KYNIEKDIAA ; HIKKEFDKKY ; 89: NPTWHCIVGR ; NFGSYVTHET ; KHFIYFYLGQ ; VAILLFKSG
Sequence Length	89
String	P63167
Sub Unit	Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with GCOM1.

Uniprot	P63167
Gene Name	DYNLL1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8655
Unigene	Hs.5120

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803559	E13866h	96T	$736		Add to Cart

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