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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Discoidin domain-containing receptor 2

SKU : BHE13803724

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1505h
Alternative Names	CD167 antigen-like family member B ; Discoidin domain-containing receptor tyrosine kinase 2 ; Neurotrophic tyrosine kinase ; receptor-related 3 ; Receptor protein-tyrosine kinase TKT ; Tyrosine-protein kinase TYRO10 ; CD167b ; NTRKR3 ; TKT ; TYRO10
Categories	Elisa
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration, cell proliferation, and cell cycle progress. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Depending on the cell type, promotes or inhibits cell proliferation. Can mediate cell cycle arrest in some types of tumor cells.
Specificity	Natural and recombinant Human Discoidin domain-containing receptor 2
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/ml
Entryname	DDR2_HUMAN
Method Type	Sandwich
Platform	PF00754
Protein Name	Discoidin domain-containing receptor 2
Sensitivity	0.078ng/mL
Sequence	50: MILIPRMLLV ; LFLLLPILSS ; AKAQVNPAIC ; RYPLGMSGGQ ; IPDEDITASS ; 100: QWSESTAAKY ; GRLDSEEGDG ; AWCPEIPVEP ; DDLKEFLQID ; LHTLHFITLV ; 150: GTQGRHAGGH ; GIEFAPMYKI ; NYSRDGTRWI ; SWRNRHGKQV ; LDGNSNPYDI ; 200: FLKDLEPPIV ; ARFVRFIPVT ; DHSMNVCMRV ; ELYGCVWLDG ; LVSYNAPAGQ ; 250: QFVLPGGSII ; YLNDSVYDGA ; VGYSMTEGLG ; QLTDGVSGLD ; DFTQTHEYHV ; 300: WPGYDYVGWR ; NESATNGYIE ; IMFEFDRIRN ; FTTMKVHCNN ; MFAKGVKIFK ; 350: EVQCYFRSEA ; SEWEPNAISF ; PLVLDDVNPS ; ARFVTVPLHH ; RMASAIKCQY ; 400: HFADTWMMFS ; EITFQSDAAM ; YNNSEALPTS ; PMAPTTYDPM ; LKVDDSNTRI ; 450: LIGCLVAIIF ; ILLAIIVIIL ; WRQFWQKMLE ; KASRRMLDDE ; MTVSLSLPSD ; 500: SSMFNNNRSS ; SPSEQGSNST ; YDRIFPLRPD ; YQEPSRLIRK ; LPEFAPGEEE ; 550: SGCSGVVKPV ; QPSGPEGVPH ; YAEADIVNLQ ; GVTGGNTYSV ; PAVTMDLLSG ; 600: KDVAVEEFPR ; KLLTFKEKLG ; EGQFGEVHLC ; EVEGMEKFKD ; KDFALDVSAN ; 650: QPVLVAVKML ; RADANKNARN ; DFLKEIKIMS ; RLKDPNIIHL ; LAVCITDDPL ; 700: CMITEYMENG ; DLNQFLSRHE ; PPNSSSSDVR ; TVSYTNLKFM ; ATQIASGMKY ; 750: LSSLNFVHRD ; LATRNCLVGK ; NYTIKIADFG ; MSRNLYSGDY ; YRIQGRAVLP ; 800: IRWMSWESIL ; LGKFTTASDV ; WAFGVTLWET ; FTFCQEQPYS ; QLSDEQVIEN ; 850: TGEFFRDQGR ; QTYLPQPAIC ; PDSVYKLMLS ; CWRRDTKNRP ; SFQEIHLLLL ; 855: QQGDE
Sequence Length	855
String	Q16832
Sub Unit	Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.

Uniprot	Q16832
Gene Name	DDR2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4921
Unigene	Hs.275757

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803724	E1505h	96T	$736		Add to Cart

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