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ELISA Kit for Human Dipeptidyl peptidase 4

SKU : BHE13803533

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0884h
Alternative Names	ADABP ; Adenosine deaminase complexing protein 2 ; ADCP-2 ; Dipeptidyl peptidase IV ; DPP IV ; T-cell activation antigen CD26 ; TP103 ; CD26 ; ADCP2 ; CD26
Categories	Elisa
Function	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Specificity	Natural and recombinant Human Dipeptidyl peptidase 4
Subcellular Location	Cell membrane Single-pass type II membrane protein Apical cell membrane Single-pass type II membrane protein Cell projection invadopodium membrane Single-pass type II membrane protein Cell projection lamellipodium membrane Single-pass type II membrane protein Cell junction Membrane raft Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface.
Detection Range	62.5-4000ng/mL
Entryname	DPP4_HUMAN
Method Type	Sandwich
Platform	PF00930
Protein Name	Dipeptidyl peptidase 4
Sensitivity	30.5ng/mL
Sequence	50: MKTPWKVLLG ; LLGAAALVTI ; ITVPVVLLNK ; GTDDATADSR ; KTYTLTDYLK ; 100: NTYRLKLYSL ; RWISDHEYLY ; KQENNILVFN ; AEYGNSSVFL ; ENSTFDEFGH ; 150: SINDYSISPD ; GQFILLEYNY ; VKQWRHSYTA ; SYDIYDLNKR ; QLITEERIPN ; 200: NTQWVTWSPV ; GHKLAYVWNN ; DIYVKIEPNL ; PSYRITWTGK ; EDIIYNGITD ; 250: WVYEEEVFSA ; YSALWWSPNG ; TFLAYAQFND ; TEVPLIEYSF ; YSDESLQYPK ; 300: TVRVPYPKAG ; AVNPTVKFFV ; VNTDSLSSVT ; NATSIQITAP ; ASMLIGDHYL ; 350: CDVTWATQER ; ISLQWLRRIQ ; NYSVMDICDY ; DESSGRWNCL ; VARQHIEMST ; 400: TGWVGRFRPS ; EPHFTLDGNS ; FYKIISNEEG ; YRHICYFQID ; KKDCTFITKG ; 450: TWEVIGIEAL ; TSDYLYYISN ; EYKGMPGGRN ; LYKIQLSDYT ; KVTCLSCELN ; 500: PERCQYYSVS ; FSKEAKYYQL ; RCSGPGLPLY ; TLHSSVNDKG ; LRVLEDNSAL ; 550: DKMLQNVQMP ; SKKLDFIILN ; ETKFWYQMIL ; PPHFDKSKKY ; PLLLDVYAGP ; 600: CSQKADTVFR ; LNWATYLAST ; ENIIVASFDG ; RGSGYQGDKI ; MHAINRRLGT ; 650: FEVEDQIEAA ; RQFSKMGFVD ; NKRIAIWGWS ; YGGYVTSMVL ; GSGSGVFKCG ; 700: IAVAPVSRWE ; YYDSVYTERY ; MGLPTPEDNL ; DHYRNSTVMS ; RAENFKQVEY ; 750: LLIHGTADDN ; VHFQQSAQIS ; KALVDVGVDF ; QAMWYTDEDH ; GIASSTAHQH ; 766: IYTHMSHFIK ; QCFSLP
Sequence Length	766
String	P27487
Sub Unit	Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.

Uniprot	P27487
Gene Name	DPP4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1803
Unigene	Hs.368912

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803533	E0884h	96T	$536		Add to Cart

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