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ELISA Kit for Human Dentin matrix acidic phosphoprotein 1

SKU : BHE13812122

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2078h
Categories	Elisa
Function	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Specificity	Natural and recombinant Human Dentin matrix acidic phosphoprotein 1
Subcellular Location	Nucleus Cytoplasm Secreted extracellular space extracellular matrix In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Detection Range	7.8-500pg/mL
Entryname	DMP1_HUMAN
Method Type	Sandwich
Platform	PF07263
Protein Name	Dentin matrix acidic phosphoprotein 1
Sensitivity	3.9pg/mL
Sequence	50: MKISILLMFL ; WGLSCALPVT ; RYQNNESEDS ; EEWKGHLAQA ; PTPPLESSES ; 100: SEGSKVSSEE ; QANEDPSDST ; QSEEGLGSDD ; HQYIYRLAGG ; FSRSTGKGGD ; 150: DKDDDEDDSG ; DDTFGDDDSG ; PGPKDRQEGG ; NSRLGSDEDS ; DDTIQASEES ; 200: APQGQDSAQD ; TTSESRELDN ; EDRVDSKPEG ; GDSTQESESE ; EHWVGGGSDG ; 250: ESSHGDGSEL ; DDEGMQSDDP ; ESIRSERGNS ; RMNSAGMKSK ; ESGENSEQAN ; 300: TQDSGGSQLL ; EHPSRKIFRK ; SRISEEDDRS ; ELDDNNTMEE ; VKSDSTENSN ; 350: SRDTGLSQPR ; RDSKGDSQED ; SKENLSQEES ; QNVDGPSSES ; SQEANLSSQE ; 400: NSSESQEEVV ; SESRGDNPDP ; TTSYVEDQED ; SDSSEEDSSH ; TLSHSKSESR ; 450: EEQADSESSE ; SLNFSEESPE ; SPEDENSSSQ ; EGLQSHSSSA ; ESQSEESHSE ; 500: EDDSDSQDSS ; RSKEDSNSTE ; SKSSSEEDGQ ; LKNIEIESRK ; LTVDAYHNKP ; 513: IGDQDDNDCQ ; DGY
Sequence Length	513
String	Q13316
Sub Unit	Interacts with importin alpha.

Uniprot	Q13316
Gene Name	DMP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1758
Unigene	Hs.652366

Reference	1. "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II." Hirst K.L., Simmons D., Feng J., Aplin H., Dixon M.J., McDougall M. Genomics42:38-45(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Molar. 2. McDougall M., Juan X., Simmons D., Feng J. Submitted (1996-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT CYS-69 3. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.more... Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 5. "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21." Aplin H.M., Hirst K.L., Crosby A.H., Dixon M.J. Genomics30:347-349(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 462-513;GENE MAPPING 6. "Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store." Narayanan K., Ramachandran A., Hao J., He G., Park K.W., Cho M., George A. J. Biol. Chem.278:17500-17508(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH IMPORTIN ALPHA 7. "DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis." Lorenz-Depiereux B., Bastepe M., Benet-Pages A., Amyere M., Wagenstaller J., Mueller-Barth U., Badenhoop K., Kaiser S.M., Rittmaster R.S., Shlossberg A.H., Olivares J.L., Loris C., Ramos F.J., Glorieux F., Vikkula M., Jueppner H., Strom T.M. Nat. Genet.38:1248-1250(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ARHR1;VARIANTS CYS-69; ASN-117 AND HIS-272 8. "Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism." Feng J.Q., Ward L.M., Liu S., Lu Y., Xie Y., Yuan B., Yu X., Rauch F., Davis S.I., Zhang S., Rios H., Drezner M.K., Quarles L.D., Bonewald L.F., White K.E. Nat. Genet.38:1310-1315(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ARHR1 9. "Secreted kinase phosphorylates extracellular proteins that regulate biomineralization." Tagliabracci V.S., Engel J.L., Wen J., Wiley S.E., Worby C.A., Kinch L.N., Xiao J., Grishin N.V., Dixon J.E. Science336:1150-1153(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FAM20C

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