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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Death-associated protein kinase 3

SKU : BHE13802977

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15322h
Alternative Names	DAP-like kinase ; Dlk ; MYPT1 kinase ; Zipper-interacting protein kinase ; ZIP-kinase ; ZIPK
Categories	Elisa
Function	Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
Specificity	Natural and recombinant Human Death-associated protein kinase 3
Subcellular Location	Nucleus Cytoplasm Nucleus PML body Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase.
Entryname	DAPK3_HUMAN
Platform	PF00069
Protein Name	Death-associated protein kinase 3
Sequence	50: MSTFRQEDVE ; DHYEMGEELG ; SGQFAIVRKC ; RQKGTGKEYA ; AKFIKKRRLS ; 100: SSRRGVSREE ; IEREVNILRE ; IRHPNIITLH ; DIFENKTDVV ; LILELVSGGE ; 150: LFDFLAEKES ; LTEDEATQFL ; KQILDGVHYL ; HSKRIAHFDL ; KPENIMLLDK ; 200: NVPNPRIKLI ; DFGIAHKIEA ; GNEFKNIFGT ; PEFVAPEIVN ; YEPLGLEADM ; 250: WSIGVITYIL ; LSGASPFLGE ; TKQETLTNIS ; AVNYDFDEEY ; FSNTSELAKD ; 300: FIRRLLVKDP ; KRRMTIAQSL ; EHSWIKAIRR ; RNVRGEDSGR ; KPERRRLKTT ; 350: RLKEYTIKSH ; SSLPPNNSYA ; DFERFSKVLE ; EAAAAEEGLR ; ELQRSRRLCH ; 400: EDVEALAAIY ; EEKEAWYREE ; SDSLGQDLRR ; LRQELLKTEA ; LKRQAQEEAK ; 450: GALLGTSGLK ; RRFSRLENRY ; EALAKQVASE ; MRFVQDLVRA ; LEQEKLQGVE ; 454: CGLR
Sequence Length	454
String	O43293
Sub Unit	Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF, CDC5L, UBE2D1, UBE2D2 AND UBE2D3.

Uniprot	O43293
Gene Name	DAPK3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1613
Unigene	Hs.631844

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SKU	Supplier No.	Size	Your price	Quantity
BHE13802977	E15322h	96T	$736		Add to Cart

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