Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Specificity
Natural and recombinant Human Cytochrome P450 2E1
Subcellular Location
Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein