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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Cellular tumor antigen p53

SKU : BHE13808364

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0928h
Alternative Names	Antigen NY-CO-13 ; Phosphoprotein p53 ; Tumor suppressor p53 ; P53
Categories	Elisa
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Specificity	Natural and recombinant Human Cellular tumor antigen p53
Subcellular Location	Isoform 9 Cytoplasm
Detection Range	0.156-10ng/ml
Entryname	P53_HUMAN
Method Type	Sandwich
Platform	PF00870
Protein Name	Cellular tumor antigen p53
Sensitivity	0.089ng/mL
Sequence	50: MEEPQSDPSV ; EPPLSQETFS ; DLWKLLPENN ; VLSPLPSQAM ; DDLMLSPDDI ; 100: EQWFTEDPGP ; DEAPRMPEAA ; PPVAPAPAAP ; TPAAPAPAPS ; WPLSSSVPSQ ; 150: KTYQGSYGFR ; LGFLHSGTAK ; SVTCTYSPAL ; NKMFCQLAKT ; CPVQLWVDST ; 200: PPPGTRVRAM ; AIYKQSQHMT ; EVVRRCPHHE ; RCSDSDGLAP ; PQHLIRVEGN ; 250: LRVEYLDDRN ; TFRHSVVVPY ; EPPEVGSDCT ; TIHYNYMCNS ; SCMGGMNRRP ; 300: ILTIITLEDS ; SGNLLGRNSF ; EVRVCACPGR ; DRRTEEENLR ; KKGEPHHELP ; 350: PGSTKRALPN ; NTSSSPQPKK ; KPLDGEYFTL ; QIRGRERFEM ; FRELNEALEL ; 393: KDAQAGKEPG ; GSRAHSSHLK ; SKKGQSTSRH ; KKLMFKTEGP ; DSD
Sequence Length	393
String	P04637
Sub Unit	Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and P53DINP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons.

Uniprot	P04637
Gene Name	TP53
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7157
Unigene	Hs.437460

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808364	E0928h	96T	$736		Add to Cart

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