CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
Specificity
Natural and recombinant Human Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.
"Human calcium/calmodulin-dependent protein kinase II: cDNA cloning and gene analysis." Li G.Y., Cooper N.G.F. Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
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