G-26 T-lymphocyte-secreted protein ; HC21 ; Lymphocyte activation gene 1 protein ; LAG-1 ; MIP-1-beta(1-69) ; Macrophage inflammatory protein 1-beta ; MIP-1-beta ; PAT 744 ; Protein H400 ; SIS-gamma ; Small-inducible cytokine A4 ; T-cell activation protein 2 ; ACT-2 ; LAG1 ; MIP1B ; SCYA4
Categories
Elisa
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Specificity
Natural and recombinant Human C-C motif chemokine 4