HC11 ; Monocyte chemoattractant protein 1 ; Monocyte chemotactic and activating factor ; MCAF ; Monocyte chemotactic protein 1 ; MCP-1 ; Monocyte secretory protein JE ; Small-inducible cytokine A2 ; MCP1 ; SCYA2
Categories
Elisa
Function
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Specificity
Natural and recombinant Human C-C motif chemokine 2
Subcellular Location
Secreted
Detection Range
15.6-1000pg/mL
Entryname
CCL2_HUMAN
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CCL2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤4.3%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.5%
Protein Name
C-C motif chemokine 2
Recovery
Recovery was determined by spiking various levels of CCL2 into serum and plasma .
Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.