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ELISA Kit for Human C-C motif chemokine 15

SKU : BHE13801511

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0272h
Alternative Names	Chemokine CC-2 ; HCC-2 ; Leukotactin-1 ; LKN-1 ; MIP-1 delta ; Macrophage inflammatory protein 5 ; MIP-5 ; Mrp-2b ; NCC-3 ; Small-inducible cytokine A15 ; MIP5 ; NCC3 ; SCYA15
Categories	Elisa
Function	Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Specificity	Natural and recombinant Human C-C motif chemokine 15
Subcellular Location	Secreted
Detection Range	0.156-10ng/mL
Entryname	CCL15_HUMAN
Method Type	Sandwich
Platform	PF00048
Protein Name	C-C motif chemokine 15
Sensitivity	0.098ng/mL
Sequence	50: MKVSVAALSC ; LMLVAVLGSQ ; AQFINDAETE ; LMMSKLPLEN ; PVVLNSFHFA ; 100: ADCCTSYISQ ; SIPCSLMKSY ; FETSSECSKP ; GVIFLTKKGR ; QVCAKPSGPG ; 113: VQDCMKKLKP ; YSI
Sequence Length	113
String	Q16663
Sub Unit	Monomer.

Uniprot	Q16663
Gene Name	CCL15
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6359
Unigene	Hs.272493

Reference	1. "Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3." Youn B.-S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S. J. Immunol.159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-24 2. "Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10." Wang W., Bacon K.B., Oldham E.R., Schall T.J. J. Clin. Immunol.18:214-222(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Spleen. 3. "HCC-2, a human chemokine: gene structure, expression pattern, and biological activity." Pardigol A., Forssmann U., Zucht H.-D., Loetscher P., Schulz-Knappe P., Baggiolini M., Forssmann W.-G., Maegert H.-J. Proc. Natl. Acad. Sci. U.S.A.95:6308-6313(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-24;CHARACTERIZATION tissue: Liver. 4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES." Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O. J. Interferon Cytokine Res.19:227-234(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-24 5. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.more... Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT THR-24 6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-24 tissue: Brain. 7. Coulin F., Power C.A., Alouani S., Peitsch M.C., Schroeder J.-M., Moshizuki M., Clark-Lewis I., Wells T.N.C. Submitted (1997-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-113 8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-36 9. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases." Wells T.N.C., Peitsch M.C. J. Leukoc. Biol.61:545-550(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCUSSION OF SEQUENCE 10. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1." Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S. Blood91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 11. "Proteolytic activation of alternative CCR1 ligands in inflammation." Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J. J. Immunol.174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF CCL15(22-92); CCL15(25-92) AND CCL15(29-92);PROTEOLYTIC PROCESSING OF N-TERMINUS;TISSUE SPECIFICITY;FUNCTION 12. "Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype." Sticht H., Escher S.E., Schweimer K., Forssmann W.G., Rosch P., Adermann K. Biochemistry38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 48-113;SUBUNIT;DISULFIDE BONDS

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