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ELISA Kit for Human Bone morphogenetic protein 4

SKU : BHE13801440

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0014h
Alternative Names	Bone morphogenetic protein 2B ; BMP-2B ; BMP2B ; DVR4
Categories	Elisa
Function	Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
Specificity	Natural and recombinant Human Bone morphogenetic protein 4
Subcellular Location	Secreted extracellular space extracellular matrix
Detection Range	31.2-2000pg/mL
Entryname	BMP4_HUMAN
Method Type	Sandwich
Platform	PF00019
Protein Name	Bone morphogenetic protein 4
Sensitivity	15.6pg/mL
Sequence	50: MIPGNRMLMV ; VLLCQVLLGG ; ASHASLIPET ; GKKKVAEIQG ; HAGGRRSGQS ; 100: HELLRDFEAT ; LLQMFGLRRR ; PQPSKSAVIP ; DYMRDLYRLQ ; SGEEEEEQIH ; 150: STGLEYPERP ; ASRANTVRSF ; HHEEHLENIP ; GTSENSAFRF ; LFNLSSIPEN ; 200: EVISSAELRL ; FREQVDQGPD ; WERGFHRINI ; YEVMKPPAEV ; VPGHLITRLL ; 250: DTRLVHHNVT ; RWETFDVSPA ; VLRWTREKQP ; NYGLAIEVTH ; LHQTRTHQGQ ; 300: HVRISRSLPQ ; GSGNWAQLRP ; LLVTFGHDGR ; GHALTRRRRA ; KRSPKHHSQR ; 350: ARKKNKNCRR ; HSLYVDFSDV ; GWNDWIVAPP ; GYQAFYCHGD ; CPFPLADHLN ; 400: STNHAIVQTL ; VNSVNSSIPK ; ACCVPTELSA ; ISMLYLDEYD ; KVVLKNYQEM ; 408: VVEGCGCR
Sequence Length	408
String	P12644
Sub Unit	Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD.

Uniprot	P12644
Gene Name	BMP4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:652
Unigene	Hs.68879

Reference	1. "Novel regulators of bone formation: molecular clones and activities." Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A. Science242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation." Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A., Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S. Calcif. Tissue Int.63:221-229(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-152 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-152 tissue: Duodenum. 4. "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S. DNA Seq.5:273-275(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-408 tissue: Placenta. 5. "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney." Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S., Akiyama T., Miyazono K., Yanagisawa M., Sakurai T. Biochem. Biophys. Res. Commun.316:490-500(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOSTDC1 6. "Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)." Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E., Ermert A., Koch M.C. Eur. J. Hum. Genet.10:753-756(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367 7. "Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways." Bakrania P., Efthymiou M., Klein J.C., Salt A., Bunyan D.J., Wyatt A., Ponting C.P., Martin A., Williams S., Lindley V., Gilmore J., Restori M., Robson A.G., Neveu M.M., Holder G.E., Collin J.R.O., Robinson D.O., Farndon P., Johansen-Berg H., Gerrelli D., Ragge N.K.more... Am. J. Hum. Genet.82d:304-319(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MCOPS6 GLY-93 8. "SIX2 and BMP4 mutations associate with anomalous kidney development." Weber S., Taylor J.C., Winyard P., Baker K.F., Sullivan-Brown J., Schild R., Knueppel T., Zurowska A.M., Caldas-Alfonso A., Litwin M., Emre S., Ghiggeri G.M., Bakkaloglu A., Mehls O., Antignac C., Schaefer F., Burdine R.D. J. Am. Soc. Nephrol.19:891-903(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-91; SER-116 AND LYS-150 9. "Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip." Suzuki S., Marazita M.L., Cooper M.E., Miwa N., Hing A., Jugessur A., Natsume N., Shimozato K., Ohbayashi N., Suzuki Y., Niimi T., Minami K., Yamamoto M., Altannamar T.J., Erkhembaatar T., Furukawa H., Daack-Hirsch S., L'heureux J., Brandon C.A., Weinberg S.M., Neiswanger K., Deleyiannis F.W., de Salamanca J.E., Vieira A.R., Lidral A.C., Martin J.F., Murray J.C.more... Am. J. Hum. Genet.84:406-411(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346;VARIANTS ALA-102; ALA-152 AND ALA-168

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