Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Specificity
Natural and recombinant Human Beta-secretase 2
Subcellular Location
Membrane Single-pass type I membrane protein Golgi apparatus Endoplasmic reticulum Endosome Cell surface