JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Autoimmune regulator

SKU : BHE13800385

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E13302h
Alternative Names	Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein ; APECED protein ; APECED
Categories	Elisa
Function	Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Specificity	Natural and recombinant Human Autoimmune regulator
Subcellular Location	Nucleus Cytoplasm Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm.
Detection Range	0.312-20ng/mL
Entryname	AIRE_HUMAN
Method Type	Sandwich
Platform	PF00628
Protein Name	Autoimmune regulator
Sensitivity	0.2ng/ml
Sequence	50: MATDAALRRL ; LRLHRTEIAV ; AVDSAFPLLH ; ALADHDVVPE ; DKFQETLHLK ; 100: EKEGCPQAFH ; ALLSWLLTQD ; STAILDFWRV ; LFKDYNLERY ; GRLQPILDSF ; 150: PKDVDLSQPR ; KGRKPPAVPK ; ALVPPPRLPT ; KRKASEEARA ; AAPAALTPRG ; 200: TASPGSQLKA ; KPPKKPESSA ; EQQRLPLGNG ; IQTMSASVQR ; AVAMSSGDVP ; 250: GARGAVEGIL ; IQQVFESGGS ; KKCIQVGGEF ; YTPSKFEDSG ; SGKNKARSSS ; 300: GPKPLVRAKG ; AQGAAPGGGE ; ARLGQQGSVP ; APLALPSDPQ ; LHQKNEDECA ; 350: VCRDGGELIC ; CDGCPRAFHL ; ACLSPPLREI ; PSGTWRCSSC ; LQATVQEVQP ; 400: RAEEPRPQEP ; PVETPLPPGL ; RSAGEEVRGP ; PGEPLAGMDT ; TLVYKHLPAP ; 450: PSAAPLPGLD ; SSALHPLLCV ; GPEGQQNLAP ; GARCGVCGDG ; TDVLRCTHCA ; 500: AAFHWRCHFP ; AGTSRPGTGL ; RCRSCSGDVT ; PAPVEGVLAP ; SPARLAPGPA ; 545: KDDTASHEPA ; LHRDDLESLL ; SEHTFDGILQ ; WAIQSMARPA ; APFPS
Sequence Length	545
String	O43918
Sub Unit	Homodimer and homotetramer. Interacts with CREBBP. Interacts preferentially with histone H3 that is not methylated at 'Lys-4'. Binds with lower affinity to histone H3 that is monomethylated at 'Lys-4'. Trimethylation of histone H3 at 'Lys-4' or phosphorylation at 'Thr-3' abolish the interaction. Binds with lower affinity to histone H3 that is acetylated at 'Lys-4', or that is acetylated at 'Lys-9' or trimethylated at 'Lys-9'. Binds histone H3 that is dimethylated at 'Arg-2' with very low affinity.

Uniprot	O43918
Gene Name	AIRE
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:326
Unigene	Hs.129829

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13800385	E13302h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.