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Home / Assay Kits / ELISA Kits

ELISA Kit for Human ATP-dependent RNA helicase DDX42

SKU : BHE13803292

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14799h
Alternative Names	DEAD box protein 42 ; RNA helicase-like protein ; RHELP ; RNA helicase-related protein ; RNAHP ; SF3b DEAD box protein ; Splicing factor 3B-associated 125 kDa protein ; SF3b125
Categories	Elisa
Function	ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
Specificity	Natural and recombinant Human ATP-dependent RNA helicase DDX42
Subcellular Location	Cytoplasm Nucleus speckle Nucleus Cajal body Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.
Detection Range	78-5000pg/mL
Entryname	DDX42_HUMAN
Method Type	Sandwich
Platform	PF00270
Protein Name	ATP-dependent RNA helicase DDX42
Sensitivity	34pg/ml
Sequence	50: MNWNKGGPGT ; KRGFGFGGFA ; ISAGKKEEPK ; LPQQSHSAFG ; ATSSSSGFGK ; 100: SAPPQLPSFY ; KIGSKRANFD ; EENAYFEDEE ; EDSSNVDLPY ; IPAENSPTRQ ; 150: QFHSKPVDSD ; SDDDPLEAFM ; AEVEDQAARD ; MKRLEEKDKE ; RKNVKGIRDD ; 200: IEEEDDQEAY ; FRYMAENPTA ; GVVQEEEEDN ; LEYDSDGNPI ; APTKKIIDPL ; 250: PPIDHSEIDY ; PPFEKNFYNE ; HEEITNLTPQ ; QLIDLRHKLN ; LRVSGAAPPR ; 300: PGSSFAHFGF ; DEQLMHQIRK ; SEYTQPTPIQ ; CQGVPVALSG ; RDMIGIAKTG ; 350: SGKTAAFIWP ; MLIHIMDQKE ; LEPGDGPIAV ; IVCPTRELCQ ; QIHAECKRFG ; 400: KAYNLRSVAV ; YGGGSMWEQA ; KALQEGAEIV ; VCTPGRLIDH ; VKKKATNLQR ; 450: VSYLVFDEAD ; RMFDMGFEYQ ; VRSIASHVRP ; DRQTLLFSAT ; FRKKIEKLAR ; 500: DILIDPIRVV ; QGDIGEANED ; VTQIVEILHS ; GPSKWNWLTR ; RLVEFTSSGS ; 550: VLLFVTKKAN ; AEELANNLKQ ; EGHNLGLLHG ; DMDQSERNKV ; ISDFKKKDIP ; 600: VLVATDVAAR ; GLDIPSIKTV ; INYDVARDID ; THTHRIGRTG ; RAGEKGVAYT ; 650: LLTPKDSNFA ; GDLVRNLEGA ; NQHVSKELLD ; LAMQNAWFRK ; SRFKGGKGKK ; 700: LNIGGGGLGY ; RERPGLGSEN ; MDRGNNNVMS ; NYEAYKPSTG ; AMGDRLTAMK ; 750: AAFQSQYKSH ; FVAASLSNQK ; AGSSAAGASG ; WTSAGSLNSV ; PTNSAQQGHN ; 800: SPDSPVTSAA ; KGIPGFGNTG ; NISGAPVTYP ; SAGAQGVNNT ; ASGNNSREGT ; 850: GGSNGKRERY ; TENRGSSRHS ; HGETGNRHSD ; SPRHGDGGRH ; GDGYRHPESS ; 900: SRHTDGHRHG ; ENRHGGSAGR ; HGENRGANDG ; RNGESRKEAF ; NRESKMEPKM ; 938: EPKVDSSKMD ; KVDSKTDKTA ; DGFAVPEPPK ; RKKSRWDS
Sequence Length	938
String	Q86XP3
Sub Unit	Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B155, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53.

Uniprot	Q86XP3
Gene Name	DDX42
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:11325
Unigene	Hs.702010

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803292	E14799h	96T	$736		Add to Cart

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