Breast cancer resistance protein ; CDw338 ; Mitoxantrone resistance-associated protein ; Placenta-specific ATP-binding cassette transporter ; Urate exporter ; CD338 ; ABCP ; BCRP ; BCRP1 ; MXR
Categories
Elisa
Function
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Specificity
Natural and recombinant Human ATP-binding cassette sub-family G member 2