Class E basic helix-loop-helix protein 76 ; bHLHe76 ; BHLHE76
Categories
Elisa
Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
Specificity
Natural and recombinant Human Aryl hydrocarbon receptor
Subcellular Location
Cytoplasm Nucleus Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP.