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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Aprataxin and PNK-like factor

SKU : BHE13801109

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3951h
Alternative Names	Apurinic-apyrimidinic endonuclease APLF ; PNK and APTX-like FHA domain-containing protein ; XRCC1-interacting protein 1 ; C2orf13 ; PALF ; XIP1
Categories	Elisa
Function	Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Specificity	Natural and recombinant Human Aprataxin and PNK-like factor
Subcellular Location	Nucleus Cytoplasm cytosol Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Detection Range	0.156-10ng/mL
Entryname	APLF_HUMAN
Method Type	Sandwich
Platform	PF10283
Protein Name	Aprataxin and PNK-like factor
Sensitivity	0.086ng/mL
Sequence	50: MSGGFELQPR ; DGGPRVALAP ; GETVIGRGPL ; LGITDKRVSR ; RHAILEVAGG ; 100: QLRIKPIHTN ; PCFYQSSEKS ; QLLPLKPNLW ; CYLNPGDSFS ; LLVDKYIFRI ; 150: LSIPSEVEMQ ; CTLRNSQVLD ; EDNILNETPK ; SPVINLPHET ; TGASQLEGST ; 200: EIAKTQMTPT ; NSVSFLGENR ; DCNKQQPILA ; ERKRILPTWM ; LAEHLSDQNL ; 250: SVPAISGGNV ; IQGSGKEEIC ; KDKSQLNTTQ ; QGRRQLISSG ; SSENTSAEQD ; 300: TGEECKNTDQ ; EESTISSKEM ; PQSFSAITLS ; NTEMNNIKTN ; AQRNKLPIEE ; 350: LGKVSKHKIA ; TKRTPHKEDE ; AMSCSENCSS ; AQGDSLQDES ; QGSHSESSSN ; 400: PSNPETLHAK ; ATDSVLQGSE ; GNKVKRTSCM ; YGANCYRKNP ; VHFQHFSHPG ; 450: DSDYGGVQIV ; GQDETDDRPE ; CPYGPSCYRK ; NPQHKIEYRH ; NTLPVRNVLD ; 500: EDNDNVGQPN ; EYDLNDSFLD ; DEEEDYEPTD ; EDSDWEPGKE ; DEEKEDVEEL ; 511: LKEAKRFMKR ; K
Sequence Length	511
String	Q8IW19
Sub Unit	Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5.

Uniprot	Q8IW19
Gene Name	APLF
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:200558
Unigene	Hs.720369

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801109	E3951h	96T	$736		Add to Cart

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