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ELISA Kit for Human Annexin A1

SKU : BHE13800955

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0333h
Alternative Names	Annexin I ; Annexin-1 ; Calpactin II ; Calpactin-2 ; Chromobindin-9 ; Lipocortin I ; Phospholipase A2 inhibitory protein ; p35 ; ANX1 ; LPC1
Categories	Elisa
Function	Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Specificity	Natural and recombinant Human Annexin A1
Subcellular Location	Nucleus Cytoplasm Cell projection cilium Basolateral cell membrane Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.
Detection Range	0.312-20ng/mL
Entryname	ANXA1_HUMAN
Method Type	Sandwich
Platform	PF00191
Protein Name	Annexin A1
Sensitivity	0.1ng/mL
Sequence	50: MAMVSEFLKQ ; AWFIENEEQE ; YVQTVKSSKG ; GPGSAVSPYP ; TFNPSSDVAA ; 100: LHKAIMVKGV ; DEATIIDILT ; KRNNAQRQQI ; KAAYLQETGK ; PLDETLKKAL ; 150: TGHLEEVVLA ; LLKTPAQFDA ; DELRAAMKGL ; GTDEDTLIEI ; LASRTNKEIR ; 200: DINRVYREEL ; KRDLAKDITS ; DTSGDFRNAL ; LSLAKGDRSE ; DFGVNEDLAD ; 250: SDARALYEAG ; ERRKGTDVNV ; FNTILTTRSY ; PQLRRVFQKY ; TKYSKHDMNK ; 300: VLDLELKGDI ; EKCLTAIVKC ; ATSKPAFFAE ; KLHQAMKGVG ; TRHKALIRIM ; 346: VSRSEIDMND ; IKAFYQKMYG ; ISLCQAILDE ; TKGDYEKILV ; ALCGGN
Sequence Length	346
String	P04083
Sub Unit	Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF.

Uniprot	P04083
Gene Name	ANXA1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:301
Unigene	Hs.494173

Reference	1. "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity." Wallner B.P., Mattaliano R.J., Hession C., Cate R.L., Tizard R., Sinclair L.K., Foeller C., Chow E.P., Browning J.L., Ramachandran K.L., Pepinsky R.B. Nature320:77-81(1986) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Correlation of gene and protein structure of rat and human lipocortin I." Kovacic R.T., Tizard R., Cate R.L., Frey A.Z., Wallner B.P. Biochemistry30:9015-9021(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli." Arcone R., Arpaia G., Ruoppolo M., Malorni A., Pucci P., Marino G., Ialenti A., di Rosa M., Ciliberto G. Eur. J. Biochem.211:347-355(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Cervix. tissue: Lung. 5. "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C." Varticovski L., Chahwala S.B., Whitman M., Cantley L., Schindler D., Chow E.P., Sinclair L.K., Pepinsky R.B. Biochemistry27:3682-3690(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PHOSPHORYLATION AT TYR-21 BY EGFR AND SER-27 BY PKC 6. "Characterization by tandem mass spectrometry of structural modifications in proteins." Biemann K., Scoble H.A. Science237:992-998(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY 7. "A dimeric form of lipocortin-1 in human placenta." Pepinsky R.B., Sinclair L.K., Chow E.P., O'Brine-Greco B. Biochem. J.263:97-103(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIMERIZATION 8. "Phosphorylation of annexin I by TRPM7 channel-kinase." Dorovkov M.V., Ryazanov A.G. J. Biol. Chem.279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-5 BY TRPM7 9. "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-239 AND LYS-312;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 12. "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 13. "Crystal structure of human annexin I at 2.5-A resolution." Weng X., Luecke H., Song I.S., Kang D.S., Kim S.-H., Huber R. Protein Sci.2:448-458(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) 14. "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit." Gao J., Li Y., Yan H. J. Biol. Chem.274:2971-2977(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 41-113

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