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ELISA Kit for Human Angiomotin

SKU : BHE13801125

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2294h
Alternative Names	KIAA1071
Categories	Elisa
Function	Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Specificity	Natural and recombinant Human Angiomotin
Subcellular Location	Cell junction tight junction Localized on the cell surface. May act as a transmembrane protein.
Detection Range	0.78-50ng/mL
Entryname	AMOT_HUMAN
Method Type	Sandwich
Platform	PF12240
Protein Name	Angiomotin
Sensitivity	0.34ng/mL
Sequence	50: MRNSEEQPSG ; GTTVLQRLLQ ; EQLRYGNPSE ; NRSLLAIHQQ ; ATGNGPPFPS ; 100: GSGNPGPQSD ; VLSPQDHHQQ ; LVAHAARQEP ; QGQEIQSENL ; IMEKQLSPRM ; 150: QNNEELPTYE ; EAKVQSQYFR ; GQQHASVGAA ; FYVTGVTNQK ; MRTEGRPSVQ ; 200: RLNPGKMHQD ; EGLRDLKQGH ; VRSLSERLMQ ; MSLATSGVKA ; HPPVTSAPLS ; 250: PPQPNDLYKN ; PTSSSEFYKA ; QGPLPNQHSL ; KGMEHRGPPP ; EYPFKGMPPQ ; 300: SVVCKPQEPG ; HFYSEHRLNQ ; PGRTEGQLMR ; YQHPPEYGAA ; RPAQDISLPL ; 350: SARNSQPHSP ; TSSLTSGGSL ; PLLQSPPSTR ; LSPARHPLVP ; NQGDHSAHLP ; 400: RPQQHFLPNQ ; AHQGDHYRLS ; QPGLSQQQQQ ; QQQQHHHHHH ; HQQQQQQQPQ ; 450: QQPGEAYSAM ; PRAQPSSASY ; QPVPADPFAI ; VSRAQQMVEI ; LSDENRNLRQ ; 500: ELEGCYEKVA ; RLQKVETEIQ ; RVSEAYENLV ; KSSSKREALE ; KAMRNKLEGE ; 550: IRRMHDFNRD ; LRERLETANK ; QLAEKEYEGS ; EDTRKTISQL ; FAKNKESQRE ; 600: KEKLEAELAT ; ARSTNEDQRR ; HIEIRDQALS ; NAQAKVVKLE ; EELKKKQVYV ; 650: DKVEKMQQAL ; VQLQAACEKR ; EQLEHRLRTR ; LERELESLRI ; QQRQGNCQPT ; 700: NVSEYNAAAL ; MELLREKEER ; ILALEADMTK ; WEQKYLEENV ; MRHFALDAAA ; 750: TVAAQRDTTV ; ISHSPNTSYD ; TALEARIQKE ; EEEILMANKR ; CLDMEGRIKT ; 800: LHAQIIEKDA ; MIKVLQQRSR ; KEPSKTEQLS ; CMRPAKSLMS ; ISNAGSGLLS ; 850: HSSTLTGSPI ; MEEKRDDKSW ; KGSLGILLGG ; DYRAEYVPST ; PSPVPPSTPL ; 900: LSAHSKTGSR ; DCSTQTERGT ; ESNKTAAVAP ; ISVPAPVAAA ; ATAAAITATA ; 950: ATITTTMVAA ; APVAVAAAAA ; PAAAAAPSPA ; TAAATAAAVS ; PAAAGQIPAA ; 1000: ASVASAAAVA ; PSAAAAAAVQ ; VAPAAPAPVP ; APALVPVPAP ; AAAQASAPAQ ; 1050: TQAPTSAPAV ; APTPAPTPTP ; AVAQAEVPAS ; PATGPGPHRL ; SIPSLTCNPD ; 1084: KTDGPVFHSN ; TLERKTPIQI ; LGQEPDAEMV ; EYLI
Sequence Length	1084
String	Q4VCS5
Sub Unit	Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.

Uniprot	Q4VCS5
Gene Name	AMOT
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:154796
Unigene	Hs.528051

Reference	1. "Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation." Troyanovsky B., Levchenko T., Maensson G., Matvijenko O., Holmgren L. J. Cell Biol.152:1247-1254(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;FUNCTION tissue: Placenta. 2. "Angiomotin regulates endothelial cell-cell junctions and cell motility." Bratt A., Birot O., Sinha I., Veitonmaeki N., Aase K., Ernkvist M., Holmgren L. J. Biol. Chem.280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TOPOLOGY;INTERACTION WITH ANGIOSTATIN AND MAGI1;SUBCELLULAR LOCATION 3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) tissue: Brain. 4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-543 (ISOFORM 1) tissue: Spinal cord. 6. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells." Wells C.D., Fawcett J.P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Metalnikov P., Pawson T. Cell125:535-548(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;DOMAIN;FUNCTION;IDENTIFICATION IN A COMPLEX WITH ARHGAP17; MPP5; INADL AND PARD3 7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic kidney. 8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 9. "The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation." Wang C., An J., Zhang P., Xu C., Gao K., Wu D., Wang D., Yu H., Liu J.O., Yu L. Biochem. J.444:279-289(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY NEDD4; NEDD4L AND ITCH

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