Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Specificity
Natural and recombinant Human Allograft inflammatory factor 1
Subcellular Location
Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.