JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human ALK tyrosine kinase receptor

SKU : BHE13800972

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E1113h
Alternative Names	Anaplastic lymphoma kinase ; CD246
Categories	Elisa
Function	Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Specificity	Natural and recombinant Human ALK tyrosine kinase receptor
Subcellular Location	Cell membrane Single-pass type I membrane protein Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
Detection Range	0.312-20ng/mL
Entryname	ALK_HUMAN
Method Type	Sandwich
Platform	PF00629
Protein Name	ALK tyrosine kinase receptor
Sensitivity	0.12ng/mL
Sequence	50: MGAIGLLWLL ; PLLLSTAAVG ; SGMGTGQRAG ; SPAAGPPLQP ; REPLSYSRLQ ; 100: RKSLAVDFVV ; PSLFRVYARD ; LLLPPSSSEL ; KAGRPEARGS ; LALDCAPLLR ; 150: LLGPAPGVSW ; TAGSPAPAEA ; RTLSRVLKGG ; SVRKLRRAKQ ; LVLELGEEAI ; 200: LEGCVGPPGE ; AAVGLLQFNL ; SELFSWWIRQ ; GEGRLRIRLM ; PEKKASEVGR ; 250: EGRLSAAIRA ; SQPRLLFQIF ; GTGHSSLESP ; TNMPSPSPDY ; FTWNLTWIMK ; 300: DSFPFLSHRS ; RYGLECSFDF ; PCELEYSPPL ; HDLRNQSWSW ; RRIPSEEASQ ; 350: MDLLDGPGAE ; RSKEMPRGSF ; LLLNTSADSK ; HTILSPWMRS ; SSEHCTLAVS ; 400: VHRHLQPSGR ; YIAQLLPHNE ; AAREILLMPT ; PGKHGWTVLQ ; GRIGRPDNPF ; 450: RVALEYISSG ; NRSLSAVDFF ; ALKNCSEGTS ; PGSKMALQSS ; FTCWNGTVLQ ; 500: LGQACDFHQD ; CAQGEDESQM ; CRKLPVGFYC ; NFEDGFCGWT ; QGTLSPHTPQ ; 550: WQVRTLKDAR ; FQDHQDHALL ; LSTTDVPASE ; SATVTSATFP ; APIKSSPCEL ; 600: RMSWLIRGVL ; RGNVSLVLVE ; NKTGKEQGRM ; VWHVAAYEGL ; SLWQWMVLPL ; 650: LDVSDRFWLQ ; MVAWWGQGSR ; AIVAFDNISI ; SLDCYLTISG ; EDKILQNTAP ; 700: KSRNLFERNP ; NKELKPGENS ; PRQTPIFDPT ; VHWLFTTCGA ; SGPHGPTQAQ ; 750: CNNAYQNSNL ; SVEVGSEGPL ; KGIQIWKVPA ; TDTYSISGYG ; AAGGKGGKNT ; 800: MMRSHGVSVL ; GIFNLEKDDM ; LYILVGQQGE ; DACPSTNQLI ; QKVCIGENNV ; 850: IEEEIRVNRS ; VHEWAGGGGG ; GGGATYVFKM ; KDGVPVPLII ; AAGGGGRAYG ; 900: AKTDTFHPER ; LENNSSVLGL ; NGNSGAAGGG ; GGWNDNTSLL ; WAGKSLQEGA ; 950: TGGHSCPQAM ; KKWGWETRGG ; FGGGGGGCSS ; GGGGGGYIGG ; NAASNNDPEM ; 1000: DGEDGVSFIS ; PLGILYTPAL ; KVMEGHGEVN ; IKHYLNCSHC ; EVDECHMDPE ; 1050: SHKVICFCDH ; GTVLAEDGVS ; CIVSPTPEPH ; LPLSLILSVV ; TSALVAALVL ; 1100: AFSGIMIVYR ; RKHQELQAMQ ; MELQSPEYKL ; SKLRTSTIMT ; DYNPNYCFAG ; 1150: KTSSISDLKE ; VPRKNITLIR ; GLGHGAFGEV ; YEGQVSGMPN ; DPSPLQVAVK ; 1200: TLPEVCSEQD ; ELDFLMEALI ; ISKFNHQNIV ; RCIGVSLQSL ; PRFILLELMA ; 1250: GGDLKSFLRE ; TRPRPSQPSS ; LAMLDLLHVA ; RDIACGCQYL ; EENHFIHRDI ; 1300: AARNCLLTCP ; GPGRVAKIGD ; FGMARDIYRA ; SYYRKGGCAM ; LPVKWMPPEA ; 1350: FMEGIFTSKT ; DTWSFGVLLW ; EIFSLGYMPY ; PSKSNQEVLE ; FVTSGGRMDP ; 1400: PKNCPGPVYR ; IMTQCWQHQP ; EDRPNFAIIL ; ERIEYCTQDP ; DVINTALPIE ; 1450: YGPLVEEEEK ; VPVRPKDPEG ; VPPLLVSQQA ; KREEERSPAA ; PPPLPTTSSG ; 1500: KAAKKPTAAE ; ISVRVPRGPA ; VEGGHVNMAF ; SQSNPPSELH ; KVHGSRNKPT ; 1550: SLWNPTYGSW ; FTEKPTKKNN ; PIAKKEPHDR ; GNLGLEGSCT ; VPPNVATGRL ; 1600: PGASLLLEPS ; SLTANMKEVP ; LFRLRHFPCG ; NVNYGYQQQG ; LPLEAATAPG ; 1620: AGHYEDTILK ; SKNSMNQPGP ;
Sequence Length	1620
String	Q9UM73
Sub Unit	Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1.

Uniprot	Q9UM73
Gene Name	ALK
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:238
Unigene	Hs.654469

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13800972	E1113h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.