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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Advanced glycosylation end product-specific receptor

SKU : BHE13809449

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1956h
Alternative Names	Receptor for advanced glycosylation end products ; RAGE
Categories	Elisa
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Specificity	Natural and recombinant Human Advanced glycosylation end product-specific receptor
Subcellular Location	Isoform 2 Secreted
Detection Range	31.2-2000pg/mL
Entryname	RAGE_HUMAN
Method Type	Sandwich
Platform	PF08205
Protein Name	Advanced glycosylation end product-specific receptor
Sensitivity	15.7pg/mL
Sequence	50: MAAGTAVGAW ; VLVLSLWGAV ; VGAQNITARI ; GEPLVLKCKG ; APKKPPQRLE ; 100: WKLNTGRTEA ; WKVLSPQGGG ; PWDSVARVLP ; NGSLFLPAVG ; IQDEGIFRCQ ; 150: AMNRNGKETK ; SNYRVRVYQI ; PGKPEIVDSA ; SELTAGVPNK ; VGTCVSEGSY ; 200: PAGTLSWHLD ; GKPLVPNEKG ; VSVKEQTRRH ; PETGLFTLQS ; ELMVTPARGG ; 250: DPRPTFSCSF ; SPGLPRHRAL ; RTAPIQPRVW ; EPVPLEEVQL ; VVEPEGGAVA ; 300: PGGTVTLTCE ; VPAQPSPQIH ; WMKDGVPLPL ; PPSPVLILPE ; IGPQDQGTYS ; 350: CVATHSSHGP ; QESRAVSISI ; IEPGEEGPTA ; GSVGGSGLGT ; LALALGILGG ; 400: LGTAALLIGV ; ILWQRRQRRG ; EERKAPENQE ; EEEERAELNQ ; SEEPEAGESS ; 404: TGGP
Sequence Length	404
String	Q15109
Sub Unit	Interacts with S100B, S100A1 and APP (By similarity). Interacts with S100A12.

Uniprot	Q15109
Gene Name	AGER
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:177
Unigene	Hs.534342

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809449	E1956h	96T	$536		Add to Cart

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