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ELISA Kit for Human Adenomatous polyposis coli protein

SKU : BHE13800858

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10944h
Alternative Names	Deleted in polyposis 2.5 ; DP2.5
Categories	Elisa
Function	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Specificity	Natural and recombinant Human Adenomatous polyposis coli protein
Subcellular Location	Cell junction adherens junction Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle membrane Cytoplasm Cell membrane Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Detection Range	0.156-10ng/mL
Entryname	APC_HUMAN
Method Type	Sandwich
Platform	PF05972
Protein Name	Adenomatous polyposis coli protein
Sensitivity	0.1ng/mL
Sequence	50: MAAASYDQLL ; KQVEALKMEN ; SNLRQELEDN ; SNHLTKLETE ; ASNMKEVLKQ ; 100: LQGSIEDEAM ; ASSGQIDLLE ; RLKELNLDSS ; NFPGVKLRSK ; MSLRSYGSRE ; 150: GSVSSRSGEC ; SPVPMGSFPR ; RGFVNGSRES ; TGYLEELEKE ; RSLLLADLDK ; 200: EEKEKDWYYA ; QLQNLTKRID ; SLPLTENFSL ; QTDMTRRQLE ; YEARQIRVAM ; 250: EEQLGTCQDM ; EKRAQRRIAR ; IQQIEKDILR ; IRQLLQSQAT ; EAERSSQNKH ; 300: ETGSHDAERQ ; NEGQGVGEIN ; MATSGNGQGS ; TTRMDHETAS ; VLSSSSTHSA ; 350: PRRLTSHLGT ; KVEMVYSLLS ; MLGTHDKDDM ; SRTLLAMSSS ; QDSCISMRQS ; 400: GCLPLLIQLL ; HGNDKDSVLL ; GNSRGSKEAR ; ARASAALHNI ; IHSQPDDKRG ; 450: RREIRVLHLL ; EQIRAYCETC ; WEWQEAHEPG ; MDQDKNPMPA ; PVEHQICPAV ; 500: CVLMKLSFDE ; EHRHAMNELG ; GLQAIAELLQ ; VDCEMYGLTN ; DHYSITLRRY ; 550: AGMALTNLTF ; GDVANKATLC ; SMKGCMRALV ; AQLKSESEDL ; QQVIASVLRN ; 600: LSWRADVNSK ; KTLREVGSVK ; ALMECALEVK ; KESTLKSVLS ; ALWNLSAHCT ; 650: ENKADICAVD ; GALAFLVGTL ; TYRSQTNTLA ; IIESGGGILR ; NVSSLIATNE ; 700: DHRQILRENN ; CLQTLLQHLK ; SHSLTIVSNA ; CGTLWNLSAR ; NPKDQEALWD ; 750: MGAVSMLKNL ; IHSKHKMIAM ; GSAAALRNLM ; ANRPAKYKDA ; NIMSPGSSLP ; 800: SLHVRKQKAL ; EAELDAQHLS ; ETFDNIDNLS ; PKASHRSKQR ; HKQSLYGDYV ; 850: FDTNRHDDNR ; SDNFNTGNMT ; VLSPYLNTTV ; LPSSSSSRGS ; LDSSRSEKDR ; 900: SLERERGIGL ; GNYHPATENP ; GTSSKRGLQI ; STTAAQIAKV ; MEEVSAIHTS ; 950: QEDRSSGSTT ; ELHCVTDERN ; ALRRSSAAHT ; HSNTYNFTKS ; ENSNRTCSMP ; 1000: YAKLEYKRSS ; NDSLNSVSSS ; DGYGKRGQMK ; PSIESYSEDD ; ESKFCSYGQY ; 1050: PADLAHKIHS ; ANHMDDNDGE ; LDTPINYSLK ; YSDEQLNSGR ; QSPSQNERWA ; 1100: RPKHIIEDEI ; KQSEQRQSRN ; QSTTYPVYTE ; STDDKHLKFQ ; PHFGQQECVS ; 1150: PYRSRGANGS ; ETNRVGSNHG ; INQNVSQSLC ; QEDDYEDDKP ; TNYSERYSEE ; 1200: EQHEEEERPT ; NYSIKYNEEK ; RHVDQPIDYS ; LKYATDIPSS ; QKQSFSFSKS ; 1250: SSGQSSKTEH ; MSSSSENTST ; PSSNAKRQNQ ; LHPSSAQSRS ; GQPQKAATCK ; 1300: VSSINQETIQ ; TYCVEDTPIC ; FSRCSSLSSL ; SSAEDEIGCN ; QTTQEADSAN ; 1350: TLQIAEIKEK ; IGTRSAEDPV ; SEVPAVSQHP ; RTKSSRLQGS ; SLSSESARHK ; 1400: AVEFSSGAKS ; PSKSGAQTPK ; SPPEHYVQET ; PLMFSRCTSV ; SSLDSFESRS ; 1450: IASSVQSEPC ; SGMVSGIISP ; SDLPDSPGQT ; MPPSRSKTPP ; PPPQTAQTKR ; 1500: EVPKNKAPTA ; EKRESGPKQA ; AVNAAVQRVQ ; VLPDADTLLH ; FATESTPDGF ; 1550: SCSSSLSALS ; LDEPFIQKDV ; ELRIMPPVQE ; NDNGNETESE ; QPKESNENQE ; 1600: KEAEKTIDSE ; KDLLDDSDDD ; DIEILEECII ; SAMPTKSSRK ; AKKPAQTASK ; 1650: LPPPVARKPS ; QLPVYKLLPS ; QNRLQPQKHV ; SFTPGDDMPR ; VYCVEGTPIN ; 1700: FSTATSLSDL ; TIESPPNELA ; AGEGVRGGAQ ; SGEFEKRDTI ; PTEGRSTDEA ; 1750: QGGKTSSVTI ; PELDDNKAEE ; GDILAECINS ; AMPKGKSHKP ; FRVKKIMDQV ; 1800: QQASASSSAP ; NKNQLDGKKK ; KPTSPVKPIP ; QNTEYRTRVR ; KNADSKNNLN ; 1850: AERVFSDNKD ; SKKQNLKNNS ; KVFNDKLPNN ; EDRVRGSFAF ; DSPHHYTPIE ; 1900: GTPYCFSRND ; SLSSLDFDDD ; DVDLSREKAE ; LRKAKENKES ; EAKVTSHTEL ; 1950: TSNQQSANKT ; QAIAKQPINR ; GQPKPILQKQ ; STFPQSSKDI ; PDRGAATDEK ; 2000: LQNFAIENTP ; VCFSHNSSLS ; SLSDIDQENN ; NKENEPIKET ; EPPDSQGEPS ; 2050: KPQASGYAPK ; SFHVEDTPVC ; FSRNSSLSSL ; SIDSEDDLLQ ; ECISSAMPKK ; 2100: KKPSRLKGDN ; EKHSPRNMGG ; ILGEDLTLDL ; KDIQRPDSEH ; GLSPDSENFD ; 2150: WKAIQEGANS ; IVSSLHQAAA ; AACLSRQASS ; DSDSILSLKS ; GISLGSPFHL ; 2200: TPDQEEKPFT ; SNKGPRILKP ; GEKSTLETKK ; IESESKGIKG ; GKKVYKSLIT ; 2250: GKVRSNSEIS ; GQMKQPLQAN ; MPSISRGRTM ; IHIPGVRNSS ; SSTSPVSKKG ; 2300: PPLKTPASKS ; PSEGQTATTS ; PRGAKPSVKS ; ELSPVARQTS ; QIGGSSKAPS ; 2350: RSGSRDSTPS ; RPAQQPLSRP ; IQSPGRNSIS ; PGRNGISPPN ; KLSQLPRTSS ; 2400: PSTASTKSSG ; SGKMSYTSPG ; RQMSQQNLTK ; QTGLSKNASS ; IPRSESASKG ; 2450: LNQMNNGNGA ; NKKVELSRMS ; STKSSGSESD ; RSERPVLVRQ ; STFIKEAPSP ; 2500: TLRRKLEESA ; SFESLSPSSR ; PASPTRSQAQ ; TPVLSPSLPD ; MSLSTHSSVQ ; 2550: AGGWRKLPPN ; LSPTIEYNDG ; RPAKRHDIAR ; SHSESPSRLP ; INRSGTWKRE ; 2600: HSKHSSSLPR ; VSTWRRTGSS ; SSILSASSES ; SEKAKSEDEK ; HVNSISGTKQ ; 2650: SKENQVSAKG ; TWRKIKENEF ; SPTNSTSQTV ; SSGATNGAES ; KTLIYQMAPA ; 2700: VSKTEDVWVR ; IEDCPINNPR ; SGRSPTGNTP ; PVIDSVSEKA ; NPNIKDSKDN ; 2750: QAKQNVGNGS ; VPMRTVGLEN ; RLNSFIQVDA ; PDQKGTEIKP ; GQNNPVPVSE ; 2800: TNESSIVERT ; PFSSSSSSKH ; SSPSGTVAAR ; VTPFNYNPSP ; RKSSADSTSA ; 2843: RPSQIPTPVN ; NNTKKRDSKT ; DSTESSGTQS ; PKRHSGSYLV ; TSV
Sequence Length	2843
String	P25054
Sub Unit	Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B.

Uniprot	P25054
Gene Name	APC
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:324
Unigene	Hs.158932

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800858	E10944h	96T	$736		Add to Cart

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