Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Specificity
Natural and recombinant Human Activity-regulated cytoskeleton-associated protein
Subcellular Location
Cytoplasm cytoskeleton Endosome Cytoplasmic vesicle secretory vesicle acrosome Cell junction synapse postsynaptic cell membrane postsynaptic density Cell projection dendrite Cell projection dendritic spine Cell junction synapse Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
Detection Range
0.156-10ng/mL
Entryname
ARC_HUMAN
Method Type
Sandwich
Protein Name
Activity-regulated cytoskeleton-associated protein