3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I ; 3-beta-HSD I ; Trophoblast antigen FDO161G ; 3BH ; HSDB3A
Categories
Elisa
Function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.
Specificity
Natural and recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Subcellular Location
Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein