ELISA Kit for Dog Thioredoxin

Mfr.No.	E0702d
Categories	Elisa
Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Specificity	Natural and recombinant Dog Thioredoxin
Subcellular Location	Nucleus Cytoplasm Secreted Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
Entryname	THIO_CANFA
Method Type	Sandwich
Protein Name	Thioredoxin
Sequence	21: MVKQIEFKYA ; FQEALNSAGD ; K
Sequence Length	21
Sub Unit	Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

Reference	1. Dunn M.J., Wheeler C.H. Submitted (1997-08) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21 tissue: Heart.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811245	E0702d	96T	$900		Add to Cart